Evaluating endophenotypes for psychiatric disorders
نویسندگان
چکیده
منابع مشابه
Genetic bases for endophenotypes in psychiatric disorders
This article reviews the concept of an endophenotype, with particular reference to heritability as well as diagnostic specificity. An endophenotype need not be heritable, for example, the possible influence of in utero viral infections for schizophrenia. However, heritability is a useful characteristic for a potential endophenotype, as it can be studied in relation to a plausible candidate gene...
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BRAINSTORMS is a monthly section of The Journal of Clinical Psychiatry aimed at providing updates of novel concepts emerging from the neurosciences that have relevance to the practicing psychiatrist. From the Neuroscience Education Institute in Carlsbad, Calif., and the Department of Psychiatry at the University of California San Diego. Reprint requests to: Stephen M. Stahl, M.D., Ph.D., Editor...
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The identification of endophenotypes in the personality disorders may provide a basis for the identification of underlying genotypes that influence the traits and dimensions of the personality disorders, as well as susceptibility to major psychiatric illnesses. Clinical dimensions of personality disorders that lend themselves to the study of corresponding endophenotypes include affective instab...
متن کاملBringing genetics back to psychiatric endophenotypes.
t T he concept of endophenotypes, introduced almost 4 decades ago, has become increasingly important in the study of complex neuropsychiatric diseases. Endophenotypes are easurable, but not overtly observable, constructs in the pathway rom genetic variation to psychiatric disorder. As originally concepualized, endophenotypes must: 1) be associated with illness in the opulation; 2) be heritable;...
متن کاملReduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders.
The reduced expression of the Sp4 gene in Sp4 hypomorphic mice resulted in subtle vacuolization in the hippocampus as well as deficits in sensorimotor gating and contextual memory, putative endophenotypes for schizophrenia and other psychiatric disorders. In this study, we examined both spatial learning/memory and hippocampal long-term potentiation (LTP) of Sp4 hypomorphic mice. Impaired spatia...
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ژورنال
عنوان ژورنال: Revista Brasileira de Psiquiatria
سال: 2006
ISSN: 1516-4446
DOI: 10.1590/s1516-44462006000200003